1 , pivaloyl chloride
Chinese alias : 2,2 – dimethyl- propionyl chloride ; trimethylammonium chloride ; tert -amyl chloride ; trimethyl acetyl chloride
Name : Pivaloyl chloride
English Name : 2,2-Dimethylpropanoyl chloride; Trimethylacetyl chloride
CAS No. : 3282-30-2
Formula : C5H9ClO
Linear Formula : (CH3) 3CCOCl
Molecular Weight : 120.58
Purity : ≥ 98.0%
No. MDL: MFCD00000709
Beilstein No. : 385668
EC Number: 221-921-6
2 Characters
Colorless oily liquid , soluble in common organic solvents , water and alkali decomposition, flammable
3, the physical parameters
Density : 0.979g/mL (25 ℃)
Boiling point :105-106 ℃
Flash point : 19 ℃
Refractive index (n20 / D): 1.412 (lit.)
4 , hazard statements
Dangerous code : F, T +
Hazard Class :11 -14-22-26-34
Security Level :16-26- 36 / 37/39-45
UN number : UN2438
Domestic hazardous chemicals No. : 81117
5 , the safety data
Hazard Symbols F; T Description
Risk Codes R11; R22; R23; R34 Description
Safety Description S16; S26; S28A; S36/37/39; S38; S45 Description
Transport Information UN 2438
6 Use (Useage)
Pivaloyl chloride is a very important acylating agent , mainly used as pharmaceutical intermediates, as the main raw material for the preparation of amides and many drugs in lipid phenol ; currently used hydroxylamine hydroxylamine benzyl benzyl penicillin and cephalosporins , cefazolin production oxazoline , double pivaloyl adrenaline and other drugs . It is also a lot to do with the production of pesticide intermediates , such Chloropivaloyl chloride.
Chemical synthesis for the protection of the amino group , while increasing the steric effect , the location of a particular product is easily obtained .