Basic Information
Chinese Name
Clotrimazole
Chinese alias
Antifungal the 1st ; triphenyl imidazole chloroformate ; chlorobenzene imidazole ; kill ringworm net ; 1 – ((2 – chlorophenyl ) diphenylmethyl )-1H- imidazol-
Name
clotrimazole crystalline
English Name
Clotrimazole ZnSO4 complex; 1 [(2-chlorophenyl) diphenylmethyl]-1H-imidazole; Clotrimazole
2CAS :23593-75-1
EINECS :245-764-8 Formula : C22H17ClN2 MW: 344.8368
3 physical and chemical properties
Appearance: white powder or colorless crystalline powder. Melting point 147-149 ℃. Relative density : 1.13g/cm3. Solubility : Soluble in ethanol , acetone , chloroform, insoluble in water . Odorless, tasteless , rapid decomposition in acid solution .
Clotrimazole hydrochloride, m.p. 159 ℃.
4 Use
Anti- fungal drugs [ 1 ] , for the treatment of skin and deep fungal infections
Raw materials
Benzene , acetone , toluene , o- chlorobenzoyl chloride , o- chloro- benzotrichloride , thionyl chloride, imidazole, aluminum trichloride, petroleum ether
Clotrimazole
A broad-spectrum anti-fungal effect . Some superficial and deep fungal fungi have antibacterial activity . The main clinical for topical treatment of skin mycosis , such as hand, foot and ringworm , tinea , ear , vaginal mycosis . This product is toxic, orally gastrointestinal reactions , abnormal liver function , and leukopenia . Has been seldom used . Topical no adverse reactions , sometimes local inflammation . Topical 1% to 3% cream ; suppositories.