Product Name: Diacerein English name: Diacerein
Molecular formula: C19H12O8 Molecular Weight: 368.29
CAS Number :13739 -02-1
Chemical name: 4,5 – diacetoxy-9 ,10 – dioxo -9,10 – dioxo– anthracene carboxylic acid
Description: orange-yellow long needles (acetone crystallized orange, yellow crystalline methanol).
Pharmacological effects
This product is an important osteoarthritis IL-1 inhibitors. After cell experiments and animal experiments confirmed: it can induce cartilage formation, has analgesic, anti-inflammatory and antipyretic effects; does not inhibit prostaglandin synthesis; osteoarthritis can delay disease progression role. Toxicology: mice and rats the maximum tolerated dose of a single person with more than 190 and 410 times the dose, the maximum tolerated dose over a dog person (dose calculation according to body surface area) with a dose 600 times subacute, chronic and fetal toxicity testing, fertility testing, perinatal and postnatal toxicity test, carcinogenic and teratogenic tests show that the drug has a good safety profile.
Drug interactions
Laxatives and the drug should not be taken together. Taking to improve intestinal transit and (or) when the nature of the drug intestinal contents, forbidden to take the drug. To improve the bioavailability of diacerein should be avoided while taking containing aluminum hydroxide and (or) magnesium hydroxide drugs. After taking diacerein increased use of antibiotics and (or) the likelihood of a patient suffering from chemotherapy enterocolitis, as antibiotics and chemotherapy affect intestinal flora.
Adverse reactions
Mild diarrhea is the application of the drug treatment of the most common side effects (incidence rate of about 7%), usually in the first few days after treatment, the appearance will automatically disappear with continued treatment in most cases. Epigastric pain 3-5% incidence of nausea or vomiting less than 1%. Taking the drug occasionally cause urine color yellow, which is a characteristic of the goods, without any clinical significance.
Taboos
This product can not be used in patients with known allergy or diacerein have allergies anthraquinone derivatives. Patients there had intestinal discomfort (especially irritable colon), we must consider the relative risks and benefits of using the drug.
Product specifications 50mg
Dosage
Long-term treatment (less than 3 months): 1-2 times a day, every one, after meals. Since taking the first two weeks of the drug may cause mild diarrhea, it is recommended that in the first four weeks of treatment a day after dinner orally. After the adaptation of the drug in patients, the dose should be increased to two times a day, after meals orally. Doctors should be determined based on the efficacy of treatment, but treatment should not be less than three months. In clinical trials, patients have been taking this product for 2 years in a row without any security issues. If the treatment requires long-term treatment in combination with other drugs, should be carried out every six months full time, including blood and urine tests, including liver enzymes. Due to the slow onset of the goods (2-4 weeks after treatment markedly) and good gastrointestinal tolerability, suggestions can be combined with other analgesics and non-steroidal anti-inflammatory drugs administered during the first 2-4 weeks Application.
【Storage】
Closed ,15-25 ℃ preservation.
[Note]
1 Plenary affect renal function does not Diacerein pharmacokinetics, it is recommended in this case (creatinine clearance <30 mL / min) to reduce the dose. Diacerein after meals can increase its absorption rate (about 24%); on the other hand, severe malnutrition would reduce the bioavailability of diacerein. Side reactions (e.g., acceleration of intestinal transit) and the amount of the direct incidence of unabsorbed on diacerein, food intake in fasted or less when using this service will increase the incidence of side effects.
2 Although animal experiments did not show that the goods have any reproductive or fetal toxicity, but the drug should not be taken during pregnancy. Meanwhile, lactating women should not take this drug, because there was a small amount of diacerein report into breast milk due to derivatives.
3 is not available for children under 15 years of age, because this age group has not conducted any clinical trials.
4 More than 70 years of age and with severe renal insufficiency (creatinine clearance 10-30 mL / min) in elderly patients required dose in half.
