Chinese alias: 2,2 – dimethyl-propionyl chloride; trimethylammonium chloride; tert-amyl chloride; trimethyl acetyl chloride
Name: Pivaloyl chloride
English Name: 2,2-Dimethylpropanoyl chloride; Trimethylacetyl chloride
CAS No.: 3282-30-2
Formula: C5H9ClO
Linear Formula: (CH3) 3CCOCl
Molecular Weight: 120.58
Purity: ≥ 98.0%
No. MDL: MFCD00000709
Beilstein No.: 385668
EC Number: 221-921-6
2 Characters
Colorless oily liquid, soluble in common organic solvents, water and alkali decomposition, flammable
Three physical parameters
Density: 0.979g/mL (25 ℃)
Boiling point :105-106 ℃
Flash point: 19 ℃
Refractive index (n20 / D): 1.412 (lit.)
4 Hazard statement
Dangerous code: F, T +
Hazard Class :11 -14-22-26-34
Security Level :16-26-36 / 37/39-45
UN number: UN2438
Domestic hazardous chemicals No.: 81117
5 Safety Data
Hazard Symbols F; T Description
Risk Codes R11; R22; R23; R34 Description
Safety Description S16; S26; S28A; S36/37/39; S38; S45 Description
Transport Information UN 2438
6 Purpose
Pivaloyl chloride is a very important acylating agent, mainly used as pharmaceutical intermediates, as the main raw material for the preparation of amides and many drugs in lipid phenol; currently used hydroxylamine hydroxylamine benzyl benzyl penicillin and cephalosporins, cefazolin production oxazoline, double pivaloyl adrenaline and other drugs. It is also a lot to do with the production of pesticide intermediates, such Chloropivaloyl chloride.
Chemical synthesis for the protection of the amino group, while increasing the steric effect, the location of a particular product is easily obtained.
