Basic information
【Common name】 povidone- iodine solution povidone-iodine ( iodine naloxone ) PVP is the English abbreviation for Poly Vinyl Pyrrolidone , Chinese name: polyvinylpyrrolidone, is a high performance , versatile sub- soluble compounds, the series Our products are widely used in textile printing and dyeing , pharmaceutical, cosmetics, beverages , adhesives, synthetic resins, detergents, paints, coatings, electronic information materials , bio- engineering materials and water treatment and other fields.
[English name] : Povidone Iodine (PVP Iodine)
[Alias] : Eric , easy speed net , Peavy iodine, pyrrolidone acid, povidone-iodine iodine ; iodine attached ; iodine naloxone ; povidone – iodine ; povidone iodine ; povidone iodine ; polyethylene iodine ; Peavy iodine ; iodine Los ketone ; solid iodine ; povidone-iodine ; Dikang Litai
[ Formula ] : C6H9I2NO (“l” on behalf of the iodine atom )
2 Indications
For suppurative dermatitis, fungal skin infection , a small area of mild burns , but also for a small area of the skin, mucous membrane wound disinfection.
3 Dosage
Can be used for skin disinfection, disinfection of skin and mucous membranes trauma , chronic sore throat , mouth ulcers.
4 pharmacological effects
This product sterilization preservatives, for a variety of bacteria , spores , viruses , fungi and other role in the killing . Its mechanism of action is the product after contact with the wound or lesion, can release free iodine depolymerization play a bactericidal effect . Organization is characterized by irritation , applied to the skin , mucous membrane infections. Can be used in a small area of the skin, mucous membrane wound disinfection.
5 Pharmaceutical Analysis
Method name: povidone-iodine – Determination of povidone iodine – potentiometric titration
Application: This method uses potentiometric titration of iodine povidone-iodine (I) levels .
This method is suitable for the determination of povidone iodine (I) iodine content .
Principle of the method : the test sample add water and stir to dissolve, according to potentiometric titration ( Appendix Ⅶ A), with sodium thiosulfate solution (0.1mol / L) titration , each 1mL sodium thiosulfate solution (0.1mol / L) equivalent to 12.69mg of I.
Reagents: (1) water ( boiling placed to room temperature )
2 sodium thiosulfate solution (0.1mol / L)
3 . Anhydrous sodium carbonate
4 KI
5 benchmark dichromate
6 . Starch indicator solution
7 . Dilute sulfuric acid
Equipment:
Sample Preparation: 1 sodium thiosulfate solution (0.1mol / L)
Preparation: 26g anhydrous sodium thiosulfate 0.20g, add boiling over cold water amount to dissolve into 1000mL, shake , place one month after filtration.
Calibration: dried to constant weight at 120 ℃ baseline potassium dichromate 0.15g, accurately weighed, set the iodine bottle , add water to dissolve 50mL , add potassium iodide 2.0g, gently shake to dissolve , add dilute sulfuric acid 40mL, shake , Mesa, in the dark for 10 minutes, diluted with water 250mL , when using the droplet to near the end , add the starch indicator solution 3mL, continue titration to the disappearance of the blue and visible light green , and titration with blank test correction . Each 1mL sodium thiosulfate solution (0.1mol / L) is equivalent to 4.903mg potassium dichromate . According to the amount of consumption of the liquid taken with potassium dichromate , calculate the concentration of the solution.
When room temperature over 25 ℃, the reaction solution should be diluted with water to cool to about 20 ℃.
2 starch indicator solution
Take soluble starch 0.5g, add water , stir 5mL , slowly pour boiling water into the 100mL , with the added with stirring and continue to boil for 2 minutes , let cool, pour supernatant , that was the solution should be Pro with the new .
3 . Dilute sulfuric acid
Sulfate 57mL, diluted with water to 1000mL.
Procedure : To about 1g, accurately weighed, set the beaker , add water 120mL, stir to dissolve, according to potentiometric titration ( Appendix Ⅶ A), with sodium thiosulfate solution (0.1mol / L) titration , each 1mL sodium thiosulfate solution (0.1mol / L) is equivalent to 12.69mg of I.
Note 1: ” Precision Weigh ” means to check the weight should be accurately referred to take the weight of one-thousandth , ” precise amount ” means to measure the accuracy of the volume should be in line with national standards for the volume pipettes accuracy.
Note 2: ” Moisture ” by drying method, take the test 2 ~ 5g, spread on drying to constant weight , flat, said bottle, no thicker than 5mm, osteoporosis test does not exceed 10mm, accurately weighed , open the bottle at 100 ~ 105 ℃ dried for 5 hours , the cap cover , remove the dryer to cool for 30 minutes, accurately weighed, weight , and then dried in the above temperature for 1 hour, cooled and weighed to twice weighing less than 5mg difference so far . According to weight loss , calculated in the test water content ( % ) .
References: People’s Republic of China , the State Pharmacopoeia Commission Code , Chemical Industry Press , 2005 edition, two , p.823.
6 role and use Edit
Strong broad-spectrum disinfectant against viruses , bacteria , fungi and mold spores have a strong role in the killing . This product is irritating to the skin , low toxicity , lasting effect . Safe and convenient. The basic non-irritating to the organization , for disinfection of the skin and mucous membranes , such as washing before surgery , surgical site and wound disinfection.
Povidone iodine, a 10% solution generally used as a disinfectant . Effectively kill : Newcastle disease, IBD , avian influenza, Mycoplasma , E. coli, salmonella , flu, blue ear disease. Parasite eggs can kill livestock , and can inhibit the breeding of mosquitoes and other insects . And can be used for fruit trees , crops, fish farming them .
7 Features
1 , the compound is a PVP-Ⅰ efficient new disinfectant antiseptic agents, 0.7% to 10 % solution in water to release the 1.8 ~ 24 ppm free iodine by the microbial oxidation of the latter from the killing effect on bacterial killing effect than Xianbi Tai , and has some lethal bacterial spores . Candida albicans drug , showed a significant role in the killing golden grapes bacteria, E. coli, Bacillus subtilis ; against Pseudomonas aeruginosa, Candida albicans sterilization time with the same concentration of compound iodine solution , iodine is similar, but only toxicity for 1 /4 to 1 /9. Compound PVP-Ⅰ toxic side effects, low price, the skin has a protective function of the mucous membrane , which was superior to anti- STD Jieeryin and aqueous potassium permanganate .
2 , in the solvent gradually release iodine , play the role of a sustained release , in order to maintain a longer sterilizing time . Mechanism of its strong sterilizing pathogens puree oxidation activity of the protein group , and capable of binding to denatured protein and amino group , thereby effectively kill bacteria, spores, fungi, protozoa, viruses and other pathogens . Has a strong bactericidal bactericidal wide range of stimulating small , stained yellow light , easy to clean, no allergic reactions and other characteristics.
3 , Staphylococcus aureus , Escherichia coli, Pseudomonas aeruginosa, Neisseria gonorrhoeae , Candida albicans and other hundreds of species of bacteria , viruses and other rapid killing effect. The product is the preferred disinfectant antiseptic drugs currently used for domestic and foreign direct human skin , mucous membranes .
4 , due to the gradual decomposition of the free iodine and work. 80 % – 90 % of the binding free depolymerization iodine iodine pathogen directly in protein denaturation , precipitation, resulting in the death of the pathogen cells to achieve efficient sterilization purposes. Which is characterized by strong bactericidal , low toxicity, and is a broad-spectrum fungicide that can kill viruses , bacteria, spores, fungi and protozoa . Against Staphylococcus aureus , Neisseria gonorrhoeae , Pseudomonas aeruginosa , Treponema pallidum , hepatitis B virus , HIV , Trichomonas vaginalis and others have a strong role in the killing .
5 , topical skin can cause allergic reactions, skin and mucous membrane irritation. Severe burns or large areas of skin exfoliation can cause systemic adverse reactions , such as metabolic acidosis, hypernatremia and renal damage, allergic to iodine , burns covering more than 20% , should not topical application , suffering from non- toxic thyroid tumors NA jelly , pregnant women and newborns should be used with caution large area . Children under 4 years of age is not recommended.
6 , broad spectrum bactericidal , fungicidal and strong, able to directly kill bacteria, fungi , viruses , spores and protozoa . Sterilization speed , most bacteria can kill within 30 seconds , five minutes is sufficient for an individual to kill bacteria . No stimulation of the skin and mucous membranes , can be used to disinfect and treat the body cavity , mucosa and ulcers . Non-toxic. Difficult to make microbes resistant , easy to allergic reactions . Use durable , good stability, long storage period . Soluble in water , easy to clean , no pollution or damage to the fabric and other items .
7 , the product acts as efficient gynecological sterilization products, its pH and vaginal similar, mild , diluted according to the instructions ( warm water ) after the effective capacity of 300ppm iodine , more than bactericidal concentrations 10-20 times , after washing can effectively kill within a variety of pathogenic microorganisms.
8 Use the
1 thermometer disinfection : 3 % concentration soaked for more than 30min , after removing 75% ethanol can be placed in the back , can also be rinsed with sterile water or cold water into the sterile container after use.
2 kinds of glassware disinfection : Available 2% to 3 % concentration soak 1 ~ 2h, due to the effect of having a wash , facilitate cleaning . For items such as carbon steel and aluminum products such as scalpel blades corrosive , not long-term immersion other metal instrument sterilization .
3 skin disinfection : 1 % to 3% scrubbing 2min, as a surgical hand disinfection before or infectious room, infectious disease specialist outpatient medical staff hand disinfection.
4 hot treatment , burn : 0.5 % solution , sprayed on the wound every 12h 1 until eschar separation so far.
5 , routine health care : for bacterial , fungal , trichomonas vaginitis , cervicitis, cervical erosion treatment. For the prevention of sexually transmitted diseases (STD), such as gonorrhea , syphilis, AIDS. Intercourse before and after menstruation clean the vagina . Gynecological surgery sterilization , disinfection before vaginal childbirth .
