In recent years, the market for fungicides has grown rapidly. In the fungicide, herbicide and pesticide three categories of pesticide new listing products, the fungicide is clearly better, more products listed, and there are many heavy products turned out. Such as BASF’s fluoxacillamides, Syngenta benzenemidazole, DuPont’s fluorothiazole acetone, Dow Agro’s Inatreq and so on. Succinate dehydrogenase inhibitors (SDHI) fungicide is self-contained to the rapid growth of the world’s attention as a dark horse.
In the new market of fungicides, not only has a new structure of the compound, a new mechanism of action of new products, which is clearly more than 20 years without new mechanism of chemical listing of herbicides far behind. New structure, the new mechanism of action, considerable market competitiveness of heavy products, etc., to promote the growth of fungicides market an important engine.
Agrochemical companies have a soft spot for SDHI fungicides
Fluoxetine amide, pyridinamide, benzenecaphenazole, biphenyl pyrithione, fluoxacillin aniline among the top five, accounting for SDHI class fungicide market 80.2%.
In recent years, the market for fungicides has grown rapidly. Pizza, Bayer and BASF and other world-leading multinational companies in the pesticide sales performance, the fungicide have occupied the most dominant position. In particular, BASF, in 2015, the company’s fungicide accounted for 45.2% of its pesticide sales, relative to the advantages of herbicides and pesticides obvious.
In all kinds of fungicides, the company on the SDHI class fungicide a soft spot. In the world’s top 20 pesticide sales, SDHI fungicides the fastest growing, may be able to explain this phenomenon. In 2015, global sales of SDHI fungicides totaled US $ 1.576 billion, up 14.9 percent year on year, and the compound annual growth rate for 2010-2015 was 29.8 percent. In these products, fluoxacillamides, pyridinamides, benzenecaphenesters, biphenylpyrazine, fluoxacillan aniline and other top five, they accounted for SDHI class fungicide market 80.2%.
Recently, the chief scientist of Sinochem International Innovation Center, Professor Liu Changling, introduced more than 20 varieties of fungicides worthy of attention.
Fluprofezamide
Fluxfluramide (fluxapyroxad) is developed by BASF SDHI class of fungicides, it is the grain, soybeans, corn and rape on the disease has excellent control effect, and has a very excellent internal combustion activity. Foliar spray and seed treatment can be. The use of the dose of 100 ~ 200 g / hm2 .In 2012, fluoroxazole amide listed, when sales of $ 95 million; 2013 sales quickly increased to 210 million US dollars; in 2014, further increased to 285 million US dollars; 2015, continue to climb to 390 million US dollars, and successfully beyond the BASF’s own product pyridinamide, SDHI fungicides become the largest product.
Pyridine amide
Benzylidene (boscalid) is also developed by BASF SDHI fungicide, listed in 2003. For the control of powdery mildew, gray mold, a variety of rot, brown rot and root rot, and other fungicides without cross-resistance. The use of the dose of 285 ~ 770 g / hm2 .In 2012, pyridinomide sales of 355 million US dollars; 2014 to 39 billion US dollars, reaching the highest level in history; 2015, its sales have declined to 3.30 Billion dollars, which will be in the SDHI class of fungicides reelected for many years to give the top position of fluoxacillin amide.
Benzenilidazole
Benzovindorfilazole (benzovindiflupyr) is the first development of SDHI class fungicide, listed in 2013. The effect of benzenecaphenazole on the rust resistance of Asian soybean was excellent. Meanwhile, the control effect of wheat leaf blight, peanut black spot, wheat total disease and wheat root rot was very good, especially for wheat powdery mildew, Corn leaf spot and gray mold have special effects; and can be mixed with a variety of fungicides, and other fungicides without cross-resistance. In 2015, global sales of benzofenazole are $ 230 million, ranking third among SDHI fungicides.
Biphenylpyrone
Bipyridamole (bixafen) is developed by Bayer SDHI fungicide, listed in 2010. For the prevention and treatment of leaf spot and leaf rust, etc., and is expected to become an important varieties of fungicide resistance. Bayer estimates that the peak sales of biphenylpyramine will exceed $ 430 million. In 2012, biphenylpyramine global sales of 100 million US dollars; in 2014, doubled to 200 million US dollars; in 2015, its sales fell 2.5 percent, to $ 195 million, but its 2010-2015 Compound annual growth rate of up to 149.9%, in the SDHI class of fungicide growth list ranked first.
Fluoxazole aniline
Fluoxacillin (penflufen) is also developed by Bayer SDHI fungicide, listed in 2012. Mainly used for potato, rape, cotton, wheat and soybean crops on the disease control, seed treatment. In 2012, the global sales of fluoxetine aniline were less than $ 30 million; sales in 2014 were $ 130 million; down by 7.7% year-on-year to $ 120 million in 2015.
Flutamide
Fluopicolide (fluopicolide) is developed by Bayer pyridine fungicides, can effectively control the disease, such as downy mildew, disease, and other fungicides without cross-resistance. The dosage is 70 to 100 g / hm2. Bayer has developed a complex product of fluticillin and fenpropanthene hydrochloride in China. The method has been developed in the United States of America (687.5 g / liter of fluoxycetin; 625 g / l) / L fulvicillin), the tomato late blight and cucumber downy mildew control effect is very good. In 2012, the global sales of flutamide accounted for $ 60 million; 2015 sales of $ 50 million.
Fluprofeizide
Fluopyramide (fluopyram) is developed by Bayer SDHI class fungicide, listed in 2012. Mainly used to control cabbage black spot, grape gray mold and barley net spot disease; also can effectively control nematodes, SDHI products is the only control of nematode fungicide. Bayer in China registered 41.7% fluproparinamide suspension agent (trade name “Lu Fidelity”), not only the prevention and treatment of cucumber powdery mildew, but also root irrigation root control nematode. In 2014 and 2015, the global sales of flutichenamide are $ 60 million.
Pydiflumetofen
Pydiflumetofen under the trade name of Adepidyn, developed codenamed SYN545974, is the latest development of the pyrazole amide fungicide, is Syngenta following pyrazolone, fluoxetine and benzenemidazole after the development of Of the new generation of SDHI class of fungicides in heavy products. 2017, first listed in Argentina. Pydiflumetofen for many small grains, corn, soybeans and special vegetables and many other crops, control gray mold, brown spot, sclerotia, etc .; also breakthroughs in the prevention of cereals caused by Fusarium disease, such as scab. According to Syngenta predicts that pydiflumetofen’s annual peak sales will exceed $ 750 million.
Isothiamine
| Amino acid original powder |
Isotianil (isotianil) is developed by Bayer / Sumitomo Chemical thiazole amide fungicide, listed in 2010. Mainly used for nursery boxes and seed treatment, control rice blast. Can be mixed with imidacloprid, polymetracycline, thiomoamide and other complex. The use of the dose of 100 ~ 300 g / hm2.2012 annual sales of $ 30 billion; 2015 sales of $ 30 billion, but the 2010-2015 compound annual growth rate as high as 65.7%.
Fluoxetine ester
Fluoxastrobin (fluoxastrobin) is developed by Bayer methacrylic acid ester fungicide, listed in 2004. Stem base diseases on the main target cereals, including diseases caused by Septoria spp., Fusarium spp., Moire disease, mold and net spot. Its application is wide, whether in the early fungi infection such as spore germination, growth of buds and immersion in the leaves, or in the mycelial growth period can provide a good protection and treatment of crops, the spore germination and early dip the most effective ; At the same time with excellent internal absorption activity and good resistance to rain erosion ability, can be used for leaf spraying or seed treatment. With a dose of 125 to 150 g / hm2. In 2014, sales of fluoxazole were $ 220 million; sales in 2015 were $ 200 million, and the compound annual growth rate for 2010-2015 was 7.4%.
Oxime ether
Oxalidomide (orysastrobin) is developed by BASF methacrylic acid ester fungicide, listed in 2007. Mainly used for rice, control rice sheath blight, rice blast, brucellosis and so on. 2014 and 2015, oxime cerevisiae sales were $ 30 billion; 2010-2015 compound annual growth rate of 14.9%.
Benzenone
Vitamin ketone (metrafenone) is developed by BASF diaryl ketone fungicide, listed in 2004. Mainly used for cereals and grapes, such as control of powdery mildew and total erosion disease. Using a dose of 75 to 150 g / hm2. 2012, the global sales of phenacetone US $ 70 million; 2015 sales of $ 60 million.
Pyribencarb
Pyribencarb is a combination of chemically developed oxime ethers (or benzyl carbamates) fungicides, available in 2012. Mainly used for fruit trees, tea and vegetables, sclerotinia, gray mold have special effects. Its 2012 sales of $ 10 billion; 2015 sales of $ 30 million.
Tolprocarb
Tolprocarb is the latest amide (or carbamate) fungicide developed by Mitsui Chemicals, listed in 2015. Mainly used for rice, control of rice blast. Using the dose of 900 ~ 1,200 g / hm2. 2015, tolprocarb sales of $ 10 billion.
Flutianil
Flutianil is a fungicide developed by Japan Otsuka Chemical Co., Ltd., listed in 2015. Mainly used for fruits and vegetables, control powdery mildew and so on. The use of the dose of 20 ~ 70 g / hm2. 2015, flutianil sales of $ 10 billion.
Fluorothiazole acetone
(Oxathiapiprolin; test code DPX-QGU42; trade name “Zengwei win green”) is developed by DuPont the first piperidinyl thiazole isoxazoline fungicide, the molecule contains four heterocycles: Oxazole, thiazole, piperidine and pyrazole; listed in 2015. Fluorothiazole acetone has a unique role in the site and a new mechanism of action, through the inhibition of oxidized steroid binding protein (OSBP) to achieve bactericidal effect. The disease has excellent control of the disease, mainly for fruits and vegetables, downy mildew and late blight disease effects, micro-toxic, the amount is very low. At present, fluorothiazole acetone is mainly used for spraying, seed processing is also one of the direction of research and development. In 2015, sales of fluoxythiazole acetone <10 billion, the product is expected to become DuPont another heavy fungicide.
Mefentrifluconazole
Mefentrifluconazole (trade name “Revysol”) is a newly developed triazole fungicide produced by BASF and is expected to be available in 2019. Mefentrifluconazole is BASF’s epoch-making new product, broad spectrum, high efficiency, internal absorption, with eradication and protection, showing excellent biological properties, is expected to become an important tool for efficient control of disease, and will be used to slow down the resistance of fungicides development of. Studies have shown that Revysol has excellent biological activity for many refractory fungal diseases and is suitable for many field crops and specialty crops such as corn, cereals, soybeans and cash crops around the world. Revysol is more effective than prothioconazole and fluconazole.
Fenpicoxamid
Fenpicoxamid (trade name “Inatreq”) is a cereal fungicide found and developed by Dow AgroSciences and is the first member of the new pyridine amide cereal fungicide. Fenpicoxamid exerts bactericidal activity by inhibiting the mitochondrial respiration of the fungal complex IIIQi ubiquinone (ie coenzyme Q) binding site. This is a new target site, which is different from the action sites of all other cereals with fungicides. Thus, fenpicoxamid has no cross-resistance with any existing cereal fungicide.
Tim Hassinger, President and CEO of Dow AgroSciences, said the company’s new fungicide, Inatreq, will improve its portfolio of fungicides. In the area of Septoria spp., Inatreq is the first compound in the industry to provide new sites of action. The product will boost the company’s sales in the European market, because the problem of resistance in Europe has become increasingly prominent.
Field experiments show that, in the recommended amount, Inatreq can effectively control all the important diseases on the grain, such as leaf blight and rust, long lasting. In addition to cereals, Dow Agents also tried to register Inatreq for other crops such as bananas. Dow Agents expect the first registration of fenpicoxamid to be achieved in 2018 and predict that the peak sales of the product will exceed $ 200 million and its market value is $ 1.5 billion.
Pesticide market will continue to grow?
The creation of new pesticides more and more difficult
| Chitosan oligosaccharide |
According to Liu Changling, since 1980, the global crop market with pesticide growth in the ups and downs. Among them, 1983 and 2006 is the history of the two valley points.
In the 15 years between 2001 and 2015, the pesticide market for crops is growing almost in addition to 2015. Among them, fruits and vegetables, soybeans, cereals, corn and rice are the top five application of pesticide market crops.
Since 1996, transgenic crops have grown at a faster rate than the growth of the global crop market with pesticides. However, according to statistics, with the increase in the area of transgenic crops, pesticide use does not increase or decrease. Such as genetically modified cotton, although the amount of pesticides used to control cotton bollworm decreased, but the control of aphids and pests of pesticide use has increased
In 2015, herbicide remains the largest product category in the global $ 1.181 billion crop pesticide market. The share of herbicides, pesticides, fungicides and other pesticides was 42.3%, 28.0%, 26.8% and 2.9% respectively. The sales were 21.444 billion, 14.33 billion, 1.713 billion and 1.523 billion respectively.
Liu Changling that the next few years, the pesticide market will continue to grow, is expected in 2015-2020, the global crop pesticide market compound annual growth rate of 2.7%; herbicides, pesticides, fungicides will be increased, 2015- The compound annual growth rates for 2020 were 2.6%, 2.4% and 3.4% respectively. Among them, the fastest growing fungicide. GM crops will also be in a growing trend, with a compound annual growth rate of 2.5% for 2015-2020.
New pesticide creation is still a difficult system engineering, whether it is time cost, or capital investment, are a lot of money data.
Syngenta statistics show that the listing of a new pesticide an average of 9 years, screening 140,000 compounds, a total investment of 260 million US dollars.
| Bacillus thuringiensis |
BASF’s statistics show that the successful listing of a new compound, the average screening of 140,000 compounds, time-consuming 10 years, need to cost 200 million euros.
Phillips McDougall’s latest research data show that the cost of new pesticide research and development increased further to 286 million US dollars, the average screening of 160,000 compounds, which lasted 11.3 years.
In short, the creation of new pesticides more and more difficult. Especially in the late toxicology test phase, will be eliminated a considerable number of pre-screening compounds. At present, China has created about 50 varieties of pesticides, of which 20 fungicides, insecticide acaricide 17, 7 herbicides, plant growth regulator 4, antiviral one.