Ethyl 4-chloroacetoacetate is an important pharmaceutical intermediates, is a treatment of cardiovascular and cerebrovascular diseases, high-performance drugs atorvastatin calcium, oxalcitrant intermediates, the drug in the United States several pharmaceutical companies have There is production. Its downstream products are mainly used for the third and fourth generation cephalosporins raw materials, cephalosporins efficacy of penicillin is several times, and the toxicity of the human body is small, development and production prospects are very good.
Ethyl 4-chloroacetoacetate Molecular formula ClCH2COCH2COOC2H5, structural formula as shown below, molecular weight 164.58, at room temperature for the colorless transparent liquid, the density of 1.218g / cm3, the boiling point of 103 ℃.
The domestic demand for ethyl 4-chloroacetoacetate is mainly determined by downstream applications.
As one of the main applications of ethyl 4-chloroacetoacetate, aminotriacetic acid was first synthesized by Alfred Huwiher and Leander Tenud, oxalated with 4-bromoacetoacetate, cyclized and methylated to form ethyl thiophosphate, and then saponified to obtain The For reasons of cost, use ethyl 4-chloroacetoacetate instead of the traditional ethyl 4-bromoacetoacetate.
China began in the early 80s of the last century the development of aminotetramine, the earliest began production of sulfamoyl acid manufacturers in Lubon Industry Co.,Ltd, when the market price of aminotetrazine as high as 60 million / ton. At that time the process is relatively cumbersome, raw material costs in 200,000 / ton, but the market demand is only about 3-5 tons. As the market continues to expand, technology is also rising. The original process is a step-by-step reaction, the need to product distillation and purification, not only caused a long process route, and the reaction yield decreased, by switching to a solvent for all reactions, and gradually reduce the cost to about 150,000, the price of the product Also reduced to 300,000 / ton or less.