Originally, the function of minoxidil is control high blood pressure, later, it was discovered that there is an interesting side effect is to reverse or slow down the balding process. Upjohn introduced a 2% minoxidil topical liquid, used to treat baldness and hair loss.
Next let us learn about Minoxidil pilatory function in the pharmacodynamic. Minoxidil pilatory function in Minoxidil (a) to stimulate follicular epithelial cell proliferation .Minoxidil Sulfate all have their role in hair growth. In vitro experiments showed that the role of minoxidil sulfate is 14 times minoxidil, if added sulfotransferase inhibitors or sulfuric acid scavengers, inhibit hair growth effects of minoxidil pilatory , but the sulfuric acid metabolite the role of no effect. Animal experiments have shown: Minoxidil pilatory can increase the dermal papilla, hair matrix, the number of fibroblasts synthetic outer root sheath and hair around, thus prolonging the hair long, and promote a hair to terminal hair transformation.
Minoxidil pilatory used for opening potassium channels: potassium channel opening is an important step in regulating hair growth in vitro and in vivo experimental animal models have shown that minoxidil pilatory is a potassium channel activator, can increase the potassium ion permeability to prevent the inflow of calcium ions within the cell when, resulting in cell free calcium concentration decreased, while calcium ions, epidermal growth factor inhibiting hair growth.
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